They do not lower androgen levels; rather, they act solely by preventing the binding of androgens to the androgen receptor.
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GnRH analogues[ edit ] In both sexes, the hypothalamus produces gonadotropin-releasing hormone GnRH to stimulate the pituitary gland to produce luteinizing hormone LH and follicle-stimulating hormone FSH.
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GnRH agonists work by initially overstimulating the pituitary gland, then rapidly desensitizing it to the effects of GnRH. After an initial surge, over a period of weeks, gonadal androgen production is greatly reduced.
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